O13-02 Carbon monoxide saturates UW solution protects ischemia/reperfusion injury of rat lung grafts
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چکیده
منابع مشابه
Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury.
Carbon monoxide (CO), a byproduct of heme catalysis by heme oxygenases, has been shown to exert anti-inflammatory effects. This study examines the cytoprotective efficacy of inhaled CO during intestinal cold ischemia/reperfusion injury associated with small intestinal transplantation. Orthotopic syngenic intestinal transplantation was performed in Lewis rats after 6 hours of cold preservation i...
متن کاملCarbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1.
RATIONALE Ventilator-induced lung injury (VILI) leads to an unacceptably high mortality. In this regard, the antiinflammatory properties of inhaled carbon monoxide (CO) may provide a therapeutic option. OBJECTIVES This study explores the mechanisms of CO-dependent protection in a mouse model of VILI. METHODS Mice were ventilated (12 ml/kg, 1-8 h) with air in the absence or presence of CO (2...
متن کاملPreconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury.
PURPOSE. Retinal ischemia/reperfusion (I/R) injury damages retinal neurons. Carbon monoxide (CO) recently attracted attention as cytoprotective because of its anti-inflammatory and antiapoptotic effects. Rapid preconditioning of retinal neurons by inhaled CO before I/R injury may reduce inflammation and apoptosis in retinal ganglion cells (RGCs). METHODS. I/R injury was performed on the left ey...
متن کاملExtended preservation of human liver grafts with UW solution.
The fate of 185 cadaveric liver homografts preserved for four to 24 hours with University of Wisconsin (UW) solution was compared with that of 180 grafts preserved for three to 9 1/2 hours with conventional Euro-Collins solution. Although the average preservation time of the UW-preserved livers was almost twice as long as that of the Euro-Collins-preserved livers, the UW-preserved grafts surviv...
متن کاملContributions Extended Preservation of Human Liver Grafts With UW Solution
The fate of 185 cadaveric liver homografts preserved for four to 24 hours with University of Wisconsin (UW) solution was compared with that of 180 grafts preserved for three to 91/2 hours with conventional Euro-Collins solution. Although the average preservation time of the UW-preserved livers was almost twice as long as that of the Euro-Collins-preserved livers, the UW-preserved grafts survive...
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ژورنال
عنوان ژورنال: The Journal of the Japanese Association for Chest Surgery
سال: 2008
ISSN: 0919-0945,1881-4158
DOI: 10.2995/jacsurg.22.431_2